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Aloin, a compound found in the exudate of some Aloe species, was the common ingredient in over-the-counter (OTC) laxative products in the United States until 2002 when the Food and Drug Administration banned it because the companies manufacturing it failed to provide the necessary safety data.
Aloe vera has potential toxicity, with side effects occurring at some dose levels both when ingested or applied topically.
Although toxicity may be less when aloin is removed by processing, Aloe vera that contains aloin in excess amounts may induce side effects.
Aloe vera juice is marketed to support the health of the digestive system, but there is neither scientific evidence nor regulatory approval to support this claim.[56] The extracts and quantities typically used for such purposes appear to be dose-dependent for toxic effects.
